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Amber becomes the patient in Wilson's Heart, where she experiences multiple organ failures as the disease progresses.The cause is revealed to be amantadine poisoning, as her kidneys were destroyed by the crash and she was unable to process the medication she was taking for the flu - amantadine was left to circulate in her system for more than a day, damaging all major organs, and making her ineligible for transplantation in the process.She drifted into the room where their patient (a drug addict she had expressed contempt for) was recovering, saying she was trying not to care.In Frozen, House was sure that Wilson was not only dating someone, but was dating someone he knew. He cornered Wilson in a fancy restaurant and was shocked when Amber showed up.Amber's ambitious personality was easily seen by the mirror patient in Mirror Mirror when he commented that he (as her) was always right and had to be.Amber tried to laugh it off, but was taken aback when he added "If they don't like you, you gotta be right -- or you're not worth anything." Like the rest of the applicants, she was saved when House decided not to fire anyone so everyone would lose their bets on the pool Chase was running to see who would be fired next. Amber wasn’t much help in Whatever It Takes, and survived because Travis Brennan deliberately poisoned the patient in order to fake a disorder then fake a cure so he could get funding to test a theory.
Main article Amber (case history) In House's Head, House is tormented by broken memories after a bus crash where he saw symptoms of an unknown disease.
He realized Amber would be the best choice because she wanted the job the most and wouldn't let him die.
In addition, the men won by default when although Thirteen got the diagnosis right, the women’s team failed to ensure the patient was treated properly and House fired all the women except Amber and Thirteen.
Lawrence Kutner ratted her out for it, but almost got fired for “squealing”.
At the end, her willingness to compete and take risks made sure she made it to the final ten.
Despite her dominating personality easily overshadowing Wilson's, she seemed to genuinely care for him, telling House that for the first time in her life she had both love and respect and didn't have to choose.